Tuesday, March 17, 2020

CHLOROQUINE? I heard this word for the first time today.

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Chloroquine

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Chloroquine
Chloroquine.svg
Clinical data
Pronunciation/ˈklɔːrəkwɪn/
Trade namesAralen, others
AHFS/Drugs.comMonograph
License data
ATC code
Legal status
Legal status
Pharmacokinetic data
MetabolismLiver
Elimination half-life1–2 months
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
NIAID ChemDB
CompTox Dashboard (EPA)
ECHA InfoCard100.000.175 Edit this at Wikidata
Chemical and physical data
FormulaC18H26ClN3
Molar mass319.872 g/mol g·mol−1
3D model (JSmol)
  (verify)
Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects.  Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. It is also occasionally used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus. It is taken by mouth.
Common side effects include muscle problems, loss of appetite, diarrhea, and skin rash. Serious side effects include problems with vision, muscle damage, seizures, and low blood cell levels. It appears to be safe for use during pregnancy.  Chloroquine is a member of the drug class 4-aminoquinoline. It works against the asexual form of malaria inside the red blood cell.
Chloroquine was discovered in 1934 by Hans Andersag. It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system. It is available as a generic medication. The wholesale cost in the developing world is about US$0.04.  In the United States, it costs about US$5.30 per dose.

Coronavirus

In trials conducted in China, chloroquine appears to be useful for coronavirus disease 2019






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